Against a standard 3-3-1 zone defense (RED), lets have our offense (BLUE) be three handlers (1, 2, 3), two poppers (4, 5), and two wings (6, 7).
The role of the handler is to maintain possession and to work the cup so we could have passing opportunities.
Poppers operate in the middle field ready to look for the first upfield passes (and crash when needed). They are constantly looking for space or are looking for where there will be space/holes. Often, one can cut to distract the side mid while the other cuts to the open area.
There is no problem for both poppers to cut to the same side. Just not at the same angle so one mid isn't stopping both poppers.
The wings usually travels close to the side line. They can strike to keep the deep D on his toes, or cut in for a yard gaining pass to the side line. If the poppers receive a first catch pass the cup, the wings are well situated for continuation cuts.
With the popper and a wing both cutting in to flood an area, we could split the mid D again.
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That is playing with 3 handlers, two poppers, two wings.
Sometime, we will need to adjust and forgo the wings, to have one deep threat to stretch their defense, and an extra handler or popper. We typically do this if the defense places a lot of pressure on the handler scrimmage line or they are stopping all the under cuts passes and we need to use some overhead passes.
When this happens. The deep threat should really pull the deep D out. We now have big pockets behind the mid Ds to throw into.
Poppers must recognize and look for those pockets however.