Middle Handler calls out "Iso [name]!" That Grover positions themselves at the front of the endzone. All others way at the back.
Grover 4 cuts side-to-side in an effort to get open. Best option is always to cut to the open (force) side first. Disc follows suit.
Cutter and disc immediately return toward middle. Cutter should have good separation from defender. It is tempting here for the handler to make a throw, but they should only do so if it's easy-peasy, lemon-squeezy.
...much better to get the disc to the side handler on a backhand...
...who then hits the cutter (who now has lots of separation) with an easy force-side forehand.
Through all of this, the other cutters stay far away to keep their defenders away from the play. Remember: on offense, space is more important than people.
If cutter 4 gets exhausted, they can call to Grover 5 by name to take over. 4 then gets out of the way along a sideline (assume the throw to them never happened), and goes to the back of the endzone, while Grover 5 shoots forward, and the process begins again.
Communication really matters here. The two people making vocal decisions are the middle handler, who chooses the ISO cutter, and that cutter, who calls for a replacement if needed. Let them do their thing.