ISO defence can be done in various ways. Playing a zone can normally mess it up sufficiently, but if our zone isn't working then you just have to play poachy man off the endzone players.
#5 on the breakside can poach shorter and stop the over the top play. This leaves #3 to stay close and worry about any throws to the open side.
D!
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A breakside short scoober is probably on, but it's not too much of a gainer.