Starting from our vert stack, the zipper play is good to run out of any dead disc, but some teams will choose to poach very hard off of the middle of the stack (the 2 or often the 3) as they know this person will not be active. If they do this that is the perfect time for zipper, although it is also effective even if they don't poach.
The 5 of the stack will fake upline a few steps, then come under hard. The 4 will do the same thing but on the breakside. This gives the Handler 2 easy options off the bat.
As they make the turn in their cuts, the 3 of the stack just runs straight deep, no cuts, just shooting deep. The handler now has 3 choices, to throw it to either the 5, hammer it or make a funny throw to the 4, or send it deep to the 3. The 4 and 5 can also put it deep if they get it.