Once we get to the endzone, our horizontal stack is less useful, because there's not enough space to threaten a deep cut.
The thrower, #6, is going to call out <i>"Iso <player's name>!"</i> Let's suppose they think #2 has a strong matchup against their defender, so they shout <i>"Iso #2!"</i>
#2 is going to move to the front of the endzone, in the middle of the open side. Everyone else is going to line up at the <i>very back</i> of the endzone, in a vertical stack.
When play starts, #2 is going to run side-to-side, trying to get open. Nobody else is involved in the offense.
#2 can cut to the sideline.
If they can't beat their defender that way, the cut hard in the opposite direction.
Even the smallest juke can lead to a goal.
What if one of the defenders in the back moves up to poach and help out?
If your defender leaves you, you need to punish them for not resepecting you.
Run to an open corner of the field for the win.